Guadalupe District Vacations from $581

Book a Hotel + Flight or Car together to unlock savings

Photo by Rick Tuers
  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Guadalupe District Vacation

Experience all the wonderful things this neighborhood has to offer with a customized Guadalupe District vacation package. However you picture yourself spending your days here, you'll find endless opportunities for adventure, relaxation and fun. When it's time to head out and explore, you'll find loads of big-name attractions nearby including Palace of the Governors, Museum of International Folk Art and Museum of Indian Arts and Culture. Visit one, two or more during your trip to Guadalupe District. Expedia will help turn your dream Guadalupe District vacation into reality, whatever your budget or travel plans.

The Latest Guadalupe District Vacation Packages

Price found within the past 48 hours. Click for updated prices.
WorldMark Santa Fe

WorldMark Santa Fe

Downtown Santa Fe
Save 100% on your flight
$581
per person
Oct 17 - Oct 20
found 5 hours ago
Roundtrip flight included
Dallas (DFW) to Albuquerque (ABQ)
9.4/10 Exceptional! (144 reviews)
Buildings are very solidly constructed and room was extremely quiet. Room was also very clean and well equipped.

Reviewed on Aug 11, 2026

The Hacienda & Spa at Hotel Santa Fe

The Hacienda & Spa at Hotel Santa Fe

Downtown Santa Fe
Save 100% on your flight
$1,043
per person
Oct 12 - Oct 15
found 1 day ago
Roundtrip flight included
Chicago (CHI) to Albuquerque (ABQ)
9.4/10 Exceptional! (1,000 reviews)
Excellent location

Reviewed on Jul 15, 2026

Hotel Zazz

Hotel Zazz

Nob Hill
$748
per person
Sep 23 - Sep 30
just found
Roundtrip flight included
Chicago (CHI) to Albuquerque (ABQ)
8.8/10 Excellent! (1,000 reviews)
I’ve stayed here multiple times and keep coming back. The pool is lovely, the location is great, and the rooms are cute. Give it a try!

Reviewed on Aug 23, 2026

La Fonda on the Plaza

La Fonda on the Plaza

Downtown Santa Fe
Save 100% on your flight
$729
per person
Oct 17 - Oct 20
found 5 hours ago
Roundtrip flight included
Dallas (DFW) to Albuquerque (ABQ)
9.2/10 Wonderful! (1,257 reviews)
Rosewood Inn of the Anasazi

Rosewood Inn of the Anasazi

Downtown Santa Fe
$1,083
per person
Oct 29 - Nov 1
found 1 day ago
Roundtrip flight included
Chicago (CHI) to Albuquerque (ABQ)
9.6/10 Exceptional! (912 reviews)
This hotel is located right in center of town so it is conveniently located. The service was outstanding from housekeeping to the restaurant to front of house staff. I thoroughly enjoyed my stay and will definitely stay here next time I visit Santa Fe.

Reviewed on Aug 20, 2026

Where to stay in Guadalupe District

Find the best Guadalupe District areas and neighborhoods for the activities you enjoy most. Learn more about Guadalupe District
A sculpture in front of a building with a unique architectural style.

Downtown Santa Fe

5 out of top 10 points of interest in this area

Visitors to Downtown Santa Fe rave about its fascinating museums, popular shops, and acclaimed art galleries. You might also want to make some time to see Santa Fe Plaza or Lensic Performing Arts Center while you're exploring the neighborhood.

A cathedral interior with stained glass windows, arched ceilings, and religious statues.

Southside

1 out of top 10 points of interest in this area

Southside is known for its popular shops, and with sights like Meow Wolf and Recursos de Santa Fe, you won't get bored spending a day wandering around this part of Santa Fe.

A stone wall with a window featuring five vertical wooden beams.

Historic Eastside

1 out of top 10 points of interest in this area

While visiting Historic Eastside, you might make a stop by sights like Canyon Road and Indian Arts Research Center.

A church with two bell towers and a large circular window.

Northeast Santa Fe

If you're looking for some top things to see and do in Northeast Santa Fe and surrounding area, you can visit Santa Fe Plaza and New Mexico Museum of Art.

A winding road through a mountainous landscape with dense greenery and distant hills.

North Hills

While North Hills might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Santa Fe Plaza and Canyon Road.

Guadalupe District Hotel Deals

Guadalupe Inn

Guadalupe Inn

604 Agua Fria St. Santa Fe NM
Fully refundableReserve now, pay when you stay
$185 nightly
$212 total
Sep 2 - Sep 3
Total with taxes and fees
9.2/10 Wonderful! (1,010 reviews)
"Everything was well organized and set up for our stay and arrival. The room was cute, romantic, and spacious. The breakfast in the morning was the best complimentary hotel breakfast I have ever had, by far. 10/10 would recommend!"

Reviewed on Aug 21, 2026

Guadalupe Inn
Perfect downtown location in historic district- 9.5 walk score! Historic home.

Perfect downtown location in historic district- 9.5 walk score! Historic home.

Santa Fe NM
9.8/10 Exceptional! (114 reviews)
"The location was perfect for us. Great for walking our dog, short drive to restaurants, the Plaza, etc. we attended the opera and our host was kind to loan us a table for tailgating. The house is beautifully appointed and comfortable. We loved the two patios and the hanging lanterns. The TV worked ..."

Reviewed on Jul 27, 2026

Get rates
Perfect downtown location in historic district- 9.5 walk score! Historic home.
The Sage Hotel

The Sage Hotel

725 Cerrillos Rd Santa Fe NM
Fully refundableReserve now, pay when you stay
$97 nightly
$109 total
Aug 30 - Aug 31
Total with taxes and fees
The Sage Hotel
See all 1,677 properties in Guadalupe District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Guadalupe District attractions

Santa Fe Railyard

8.8/10 (1,473 reviews)
During your visit to Santa Fe, you can do some window-shopping at Santa Fe Railyard. Experience the acclaimed art scene and lively festivals in this family-friendly area.
See properties

Santuario De Nuestra Senora de Guadalupe

Find out about the history of Santa Fe when you take a trip to Santuario De Nuestra Senora de Guadalupe. Add the area's stunning cathedral or shops to your travel plans.
See properties

Santa Fe Farmers Market

You can browse for the perfect souvenirs at Santa Fe Farmers Market during your trip to Santa Fe. Add the area's shops or stunning cathedral to your travel plans.
See properties

TAI Modern

You can spend time exploring the galleries in TAI Modern during your trip to Santa Fe. Make time to visit the area's stunning cathedral, or simply enjoy its top-notch restaurants.
See properties

El Museo Cultural

You can spend time browsing the exhibits at El Museo Cultural during your trip to Santa Fe. Add the area's stunning cathedral or shops to your travel plans.
See properties

Art Vault

You can spend time studying the exhibits at Art Vault in Santa Fe. Make time to visit the area's shops, or simply enjoy its top-notch restaurants.
See properties

Things to do

Santa Fe: Meow Wolf's House of Eternal Return Ticket

Santa Fe: Meow Wolf The House of Eternal Return Ticket

$54
per adult
100% of travellers recommend
Santa Fe: Meow Wolf The House of Eternal Return Ticket
Hot Air Balloon Rides in Santa Fe

Hot Air Balloon Rides in Santa Fe

$315
per adult
Hot Air Balloon Rides in Santa Fe
Santa Fe: Canyon Road Arts District Walking Tour

Santa Fe: Canyon Road Art & History Walking Tour

$70
per adult
100% of travellers recommend
Santa Fe: Canyon Road Art & History Walking Tour
See all activities in Santa Fe
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.